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Autosomal Dominant and Recessive Inheritance

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  • Autosomal Dominant and Recessive Inheritance

Instructions: For this assignment, you will analyze a hypothetical family that has an unusually high occurrence of a hypothetical disease known as “X”. The disease is inherited and follows this pattern: homozygous dominant (XX) and heterozygous (Xx) genotypes provide healthy phenotypes while homozygous recessive (xx) provides the disease phenotype.

The occurrence of the disease in the family is as follows. The grandchildren have all had submitted to DNA sequencing to provide their genotypes. We only know the presence or absence of the disease for the grandparents’ and parents’ generation:

Grandfather (healthy) and Grandmother (disease) had 6 children

Child 1 (Male) died at 12

Child 2 (Female) died 29 from the disease.

Child 3 (Male with disease) married and produced two children

Female Grandchild (Heterozygous)

Female Grandchild (Heterozygous)

Child 4 (Female with disease) married and produced two children

Male Grandchild (Homozygous Dominant)

Female Grandchild (Heterozygous)

Child 5 (Stillborn at 21 weeks)

Child 6 (Female with disease) married and produced two children

Female Grandchild (Homozygous Recessive)

Male Grandchild (Heterozygous)

Assignment Expectations:

First, determine if disease “X” follows an autosomal dominant or recessive pattern of inheritance. Second, using any means (including hand drawn if necessary), construct a pedigree of the hypothetical family listed above. Provide as many geneotypes as possible for each member of the family. In many cases you will have to solve the parents genotype based on offspring. You may not be able to determine the genotype of all based on the information provided. For those instances list the possible genotypes.

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Post Tags Post TagsAutosomal Dominant and Recessive InheritanceChild 1 (Male) died at 12Child 2 (Female) died 29 from the disease.Child 4 (Female with disease) married and produced two childrenChild 5 (Stillborn at 21 weeks)Child 6 (Female with disease) married and produced two childrenconstruct a pedigree of the hypothetical family listed above.determine if disease “X” follows an autosomal dominant or recessive pattern of inheritance.Female Grandchild (Heterozygous)Female Grandchild (Homozygous Recessive)FirstFor this assignment you will analyze a hypothetical family that has an unusually high occurrence of a hypothetical disease known as “X”For those instances list the possible genotypes.Grandfather (healthy) and Grandmother (disease) had 6 childrenIn many cases you will have to solve the parents genotype based on offspring.Male Grandchild (Heterozygous)Male Grandchild (Homozygous Dominant)Provide as many geneotypes as possible for each member of the family.SecondThe disease is inherited and follows this pattern: homozygous dominant (XX) and heterozygous (Xx) genotypes provide healthy phenotypes while homozygous recessive (xx) provides the disease phenotype.The occurrence of the disease in the family is as follows. The grandchildren have all had submitted to DNA sequencing to provide their genotypes.using any means (including hand drawn if necessary)We only know the presence or absence of the disease for the grandparents’ and parents’ generation:You may not be able to determine the genotype of all based on the information provided.

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